ABSTRACT
Objective To investigate the association between the angiotensin-converting enzyme (ACE) I/D locus polymor-phism and migraine susceptibility .Methods The case control studies on the relation between ACE I/D gene polymorphism and mi-graine susceptibility published in the databases of PubMed and EMBAE were retrieved .The relationship between ACE 1/D poly-morphism and migraine was evaluated through the effect size (OR) and 95% confidence interval(CI) by fixed-effects model or ran-dom-effect models .Meanwhile the subgroup analysis of ethnicity and migraine types was performed .Results In meta analysis ,the homozygote model(DD vs .Ⅱ:OR= 1 .21 ,95% CI:1 .02-1 .44 ,P=0 .03 ;I2 =47% ) and dominant model all indicated that the ACE I/D polymorphism was positively correlated with the susceptibility of all migraine .The heterozygote model (DI vs .Ⅱ:OR=1 .35 , 95% CI:1 .06-1 .72 ,P=0 .02 ;I2 =10% ) and dominant model (DD+DI vs .Ⅱ:OR=1 .37 ,95% CI:1 .09 -1 .73 ,P=0 .00 ;I2 =40% ) indicated that ACE I/D polymorphism significantly increased the susceptibility of migraine with aura .Conclusion The ACE I/D locus polymorphism is correlated with migraine susceptibility ,its D allele is a risk factor of migraine ,which especially increases the susceptibility of migraine with aura .
ABSTRACT
Potassium metabolism in young adult men exercising in the heat for six consecutive days and the effect of potassium deficiency in mice and rats induced by low potassium diet during heat exposure were observed. Increased potassium loss in sweat and lower potassium intake resulted in negative potassium balance. Individuals with a negative potassium balance had lower se- rum potassium levels and higher body temperature after exercise. Potassium deficient mice accomplished less work done (2.372 vs 4.253 Kg.M) but exih-ibited a markedly greater rate of heat gain (1.36 vs 0.87℃/Kg.M) as compared to the controls. The survival rate and cellular energy metabolism also decreasedThese observations suggest that prevention from potassium deficiency must be emphasized during prolonged physical activity under hot environments. According to the linear regression equations between potassium intake and balance, it is proposed that the potassium requirements in mild and medium physical activity in the heat are 40 and 60 mEq/day respectively, and the allowance of potassium in the latter may be 70-80 mEq/day.